Red/near-infrared irradiation therapy for treatment of central nervous system injuries and disorders
|dc.contributor.author||Van Den Heuvel, C.|
|dc.identifier.citation||Fitzgerald, M. and Hodgetts, S. and Van Den Heuvel, C. and Natoli, R. and Hart, N. and Valter, K. and Harvey, A. et al. 2013. Red/near-infrared irradiation therapy for treatment of central nervous system injuries and disorders. Reviews in the Neurosciences. 24 (2): pp. 205-226.|
Irradiation in the red/near-infrared spectrum (R/NIR, 630 -1000 nm) has been used to treat a wide range of clinical conditions, including disorders of the central nervous system (CNS), with several clinical trials currently underway for stroke and macular degeneration. However, R/NIR irradiation therapy (R/NIR-IT) has not been widely adopted in clinical practice for CNS injury or disease for a number of reasons, which include the following. The mechanism/s of action and implications of penetration have not been thoroughly addressed. The large range of treatment intensities, wavelengths and devices that have been assessed make comparisons difficult, and a consensus paradigm for treatment has not yet emerged. Furthermore, the lack of consistent positive outcomes in randomised controlled trials, perhaps due to sub-optimal treatment regimens, has contributed to scepticism. This review provides a balanced précis of outcomes described in the literature regarding treatment modalities and efficacy of R/NIR-IT for injury and disease in the CNS. We have addressed the important issues of specification of treatment parameters, penetration of R/NIR irradiation to CNS tissues and mechanism/s, and provided the necessary detail to demonstrate the potential of R/NIR-IT for the treatment of retinal degeneration, damage to white matter tracts of the CNS, stroke and Parkinson's disease.
|dc.title||Red/near-infrared irradiation therapy for treatment of central nervous system injuries and disorders|
|dcterms.source.title||Reviews in the Neurosciences|
The final publication is available at www.degruyter.com
|curtin.department||Health Sciences Research and Graduate Studies|