Genetics of HIV-associated sensory neuropathy and related pain in Africans
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Despite the use of safer antiretroviral medications, the rate of HIV-associated sensory neuropathy (HIV-SN), the most common neurological complication of HIV, remains high. This condition is often painful and has a negative effect on quality of life. Up to 90% of those with HIV-SN experience pain for which there is no effective analgesic treatment. Genetic factors are implicated, but there is a lack of a comprehensive body of research for African populations. This knowledge gap is even more pertinent as Africans are most affected by HIV. However, recent studies performed in Southern African populations have identified genes displaying potential as genetic markers for HIV-SN and HIV-SN-associated pain in Africans. Here, we review the published studies to describe current knowledge of genetic risk factors for this disease in Africa.
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TNF Block Gene Variants Associated with Pain Intensity in Black Southern Africans with HIV-associated Sensory NeuropathyHendry, L.; Wadley, A.; Cherry, C.; Price, Patricia; Lombard, Z.; Kamerman, P. (2016)Objectives: HIV-associated sensory neuropathy (HIV-SN) is a common neurological complication of HIV infection, and often is painful. Tumour necrosis factor (TNF)-[alpha] is implicated in neuropathic pain, but associations ...
Carer experience of back pain is associated with adolescent back pain experience even when controlling for other carer and family factorsO'Sullivan, Peter; Straker, Leon; Smith, Anne; Perry, Mark; Kendall, Garth (2008)Objectives: The study objectives were (1) to determine if adolescent back pain is related to carer back pain; and (2) to examine whether other carer and family factors accounted for any such relationship. Methods: Back ...
Analysis of a previously identified "pain-protective" haplotype and individual polymorphisms in the GCH1 gene in Africans with HIV-associated sensory neuropathy: A genetic association studyWadley, A.; Lombard, Z.; Cherry, C.; Price, Patricia; Kamerman, P. (2012)We analyzed GTP cyclohydrolase 1 in symptomatic HIV-associated sensory neuropathy in Southern Africans including a "painprotective" 3-SNP haplotype and 6 SNPs, analyzed individually and in a 6-SNP haplotype. The ...