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    Genetics of HIV-associated sensory neuropathy and related pain in Africans

    Access Status
    Fulltext not available
    Authors
    Ngassa Mbenda, H.
    Wadley, A.
    Lombard, Z.
    Cherry, C.
    Price, Patricia
    Kamerman, P.
    Date
    2017
    Type
    Journal Article
    
    Metadata
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    Citation
    Ngassa Mbenda, H. and Wadley, A. and Lombard, Z. and Cherry, C. and Price, P. and Kamerman, P. 2017. Genetics of HIV-associated sensory neuropathy and related pain in Africans. Journal of NeuroVirology. 23 (4): pp. 511-519.
    Source Title
    Journal of NeuroVirology
    DOI
    10.1007/s13365-017-0532-1
    ISSN
    1355-0284
    School
    School of Biomedical Sciences
    URI
    http://hdl.handle.net/20.500.11937/57025
    Collection
    • Curtin Research Publications
    Abstract

    Despite the use of safer antiretroviral medications, the rate of HIV-associated sensory neuropathy (HIV-SN), the most common neurological complication of HIV, remains high. This condition is often painful and has a negative effect on quality of life. Up to 90% of those with HIV-SN experience pain for which there is no effective analgesic treatment. Genetic factors are implicated, but there is a lack of a comprehensive body of research for African populations. This knowledge gap is even more pertinent as Africans are most affected by HIV. However, recent studies performed in Southern African populations have identified genes displaying potential as genetic markers for HIV-SN and HIV-SN-associated pain in Africans. Here, we review the published studies to describe current knowledge of genetic risk factors for this disease in Africa.

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