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dc.contributor.authorParameswaran Nair, N.
dc.contributor.authorStafford, Leanne
dc.contributor.authorBereznicki, B.
dc.contributor.authorCurtain, C.
dc.contributor.authorPeterson, G.
dc.contributor.authorConnolly, M.
dc.contributor.authorBereznicki, L.
dc.date.accessioned2017-11-24T05:25:20Z
dc.date.available2017-11-24T05:25:20Z
dc.date.created2017-11-24T04:48:44Z
dc.date.issued2017
dc.identifier.citationParameswaran Nair, N. and Stafford, L. and Bereznicki, B. and Curtain, C. and Peterson, G. and Connolly, M. and Bereznicki, L. 2017. Adverse Drug Reaction-Related Hospitalizations in Elderly Australians: A Prospective Cross-Sectional Study in Two Tasmanian Hospitals. Drug Safety. 40 (7): pp. 597-606.
dc.identifier.urihttp://hdl.handle.net/20.500.11937/58354
dc.identifier.doi10.1007/s40264-017-0528-z
dc.description.abstract

© 2017, Springer International Publishing Switzerland. Introduction: Adverse drug reactions (ADRs) have been commonly cited as a major cause of hospital admissions in older individuals. However, despite the apparent magnitude of this problem, there are limited prospective data on ADRs as a cause of hospitalization in elderly medical patients. Objectives: The objective of this study was to evaluate the proportion, clinical characteristics, causality, severity, preventability, and outcome of ADR-related admissions in older patients admitted to two Tasmanian hospitals. Methods: We conducted a prospective cross-sectional study at the Royal Hobart and Launceston General Hospitals in Tasm ania, Australia. A convenience sample of patients, aged 65 years and older, undergoing unplanned overnight medical admissions was screened. ADR-related admissions were determined through expert consensus from detailed review of medical records and patient interviews. The causality, preventability and severity of each ADR-related admission were assessed. Results: Of 1008 admissions, the proportion of potential ADR-related medical admissions was 18.9%. Most (88.5%) ADR-related admissions were considered preventable. Cardiovascular complaints (29.3%) represented the most common ADRs, followed by neuropsychiatric (20.0%) and renal and genitourinary disorders (15.2%). The most frequently implicated drug classes were diuretics (23.9%), agents acting on the renin angiotensin system (16.4%), ß-blocking agents (7.1%), antidepressants (6.9%), and antithrombotic agents (6.9%). Application of the Naranjo algorithm found 5.8% definite, 70.1% probable, and 24.1% possible ADRs. ADR severity was rated moderate and severe in 97.9% and 2.1% of admissions, respectively. For most (93.2%) ADR-related admissions the ADR resolved and the patient recovered. Conclusion: Hospitalization due to an ADR is a common occurrence in this older population. There is need for future studies to implement and evaluate interventions to reduce the risk of ADR-related admissions in elderly populations.

dc.publisherAdis International Ltd.
dc.titleAdverse Drug Reaction-Related Hospitalizations in Elderly Australians: A Prospective Cross-Sectional Study in Two Tasmanian Hospitals
dc.typeJournal Article
dcterms.source.volume40
dcterms.source.number7
dcterms.source.startPage597
dcterms.source.endPage606
dcterms.source.issn0114-5916
dcterms.source.titleDrug Safety
curtin.departmentSchool of Pharmacy
curtin.accessStatusFulltext not available


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