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Synthesis of N-(6-(4-(Piperazin-1-yl)phenoxy)pyridin-3-yl) benzenesulfonamide Derivatives for the Treatment of Metabolic Syndrome

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Authors
Deka, N.
Bajare, S.
Anthony, J.
Nair, A.
Damre, A.
Patel, Dharmeshkumar
B-Rao, C.
Sivaramakrishnan, H.
Mutt, S.
Wilankar, C.
Marita, R.
Date
2013
Type
Journal Article

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Deka, N. and Bajare, S. and Anthony, J. and Nair, A. and Damre, A. and Patel, D. and B-Rao, C. et al. 2013. Synthesis of N-(6-(4-(Piperazin-1-yl)phenoxy)pyridin-3-yl) benzenesulfonamide Derivatives for the Treatment of Metabolic Syndrome. International Journal of Medicinal Chemistry. 2013: Article ID 201580.
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International Journal of Medicinal Chemistry
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School of Biomedical Sciences
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Abstract

Metabolic syndrome is a widely prevalent multifactorial disorder associated with an increased risk of cardiovascular disease and type 2 diabetes mellitus. High plasma levels of insulin and glucose due to insulin resistance are a major component of the metabolic disorder. Thiazolidinediones (TZDs) are potent PPARγ ligand and used as insulin sensitizers in the treatment of type 2 diabetes mellitus. They are potent insulin-sensitizing agents but due to adverse effects like hepatotoxicity, a safer alternative of TZDs is highly demanded. Here we report synthesis of N-(6-(4-(piperazin-1-yl)phenoxy)pyridin-3-yl)benzenesulfonamide derivatives as an alternate remedy for insulin resistance.

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