Synthesis of N-(6-(4-(Piperazin-1-yl)phenoxy)pyridin-3-yl) benzenesulfonamide Derivatives for the Treatment of Metabolic Syndrome
| dc.contributor.author | Deka, N. | |
| dc.contributor.author | Bajare, S. | |
| dc.contributor.author | Anthony, J. | |
| dc.contributor.author | Nair, A. | |
| dc.contributor.author | Damre, A. | |
| dc.contributor.author | Patel, Dharmeshkumar | |
| dc.contributor.author | B-Rao, C. | |
| dc.contributor.author | Sivaramakrishnan, H. | |
| dc.contributor.author | Mutt, S. | |
| dc.contributor.author | Wilankar, C. | |
| dc.contributor.author | Marita, R. | |
| dc.date.accessioned | 2017-11-28T06:36:43Z | |
| dc.date.available | 2017-11-28T06:36:43Z | |
| dc.date.created | 2017-11-28T06:21:50Z | |
| dc.date.issued | 2013 | |
| dc.identifier.citation | Deka, N. and Bajare, S. and Anthony, J. and Nair, A. and Damre, A. and Patel, D. and B-Rao, C. et al. 2013. Synthesis of N-(6-(4-(Piperazin-1-yl)phenoxy)pyridin-3-yl) benzenesulfonamide Derivatives for the Treatment of Metabolic Syndrome. International Journal of Medicinal Chemistry. 2013: Article ID 201580. | |
| dc.identifier.uri | http://hdl.handle.net/20.500.11937/58721 | |
| dc.identifier.doi | 10.1155/2013/201580 | |
| dc.description.abstract |
Metabolic syndrome is a widely prevalent multifactorial disorder associated with an increased risk of cardiovascular disease and type 2 diabetes mellitus. High plasma levels of insulin and glucose due to insulin resistance are a major component of the metabolic disorder. Thiazolidinediones (TZDs) are potent PPARγ ligand and used as insulin sensitizers in the treatment of type 2 diabetes mellitus. They are potent insulin-sensitizing agents but due to adverse effects like hepatotoxicity, a safer alternative of TZDs is highly demanded. Here we report synthesis of N-(6-(4-(piperazin-1-yl)phenoxy)pyridin-3-yl)benzenesulfonamide derivatives as an alternate remedy for insulin resistance. | |
| dc.publisher | Hindawi Ltd | |
| dc.rights.uri | http://creativecommons.org/licenses/by/3.0/ | |
| dc.title | Synthesis of N-(6-(4-(Piperazin-1-yl)phenoxy)pyridin-3-yl) benzenesulfonamide Derivatives for the Treatment of Metabolic Syndrome | |
| dc.type | Journal Article | |
| dcterms.source.issn | 2090-2069 | |
| dcterms.source.title | International Journal of Medicinal Chemistry | |
| curtin.department | School of Biomedical Sciences | |
| curtin.accessStatus | Open access |
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