Mathematical modeling of coupled drug and drug-encapsulated nanoparticle transport in patient-specific coronary artery walls
MetadataShow full item record
The majority of heart attacks occur when there is a sudden rupture of atherosclerotic plaque, exposing prothrombotic emboli to coronary blood flow, forming clots that can cause blockages of the arterial lumen. Diseased arteries can be treated with drugs delivered locally to vulnerable plaques. The objective of this work was to develop a computational tool-set to support the design and analysis of a catheter-based nanoparticulate drug delivery system to treat vulnerable plaques and diffuse atherosclerosis. A threedimensional mathematical model of coupled mass transport of drug and drug-encapsulated nanoparticles was developed and solved numerically utilizing isogeometric finite element analysis. Simulations were run on a patient-specific multilayered coronary artery wall segment with a vulnerable plaque and the effect of artery and plaque inhomogeneity was analyzed. The method captured trends observed in local drug delivery and demonstrated potential for optimizing drug design parameters, including delivery location, nanoparticle surface properties, and drug release rate. © Springer-Verlag 2011.
Showing items related by title, author, creator and subject.
Haemodynamic evaluation of coronary artery plaques : prediction of coronary atherosclerosis and disease progressionChaichana, Thanapong (2012)Coronary artery disease is the leading cause of death in advanced countries. Coronary artery disease tends to develop at locations where disturbed flow patterns occur, such as the left coronary artery. Haemodynamic change ...
Computational fluid dynamics analysis of the effect of simulated plaques in the left coronary artery: A preliminary study.Chaichana, T.; Jewkes, James; Sun, Zhonghua (2011)Background: Atherosclerosis is the most common cause of coronary artery disease which is formed by plaque presence inside the artery wall leading to blockage of the blood supply to the heart muscle. The mechanism of ...
3D virtual intravascular endoscopy visualization of coronary artery plaques: Virtual intravascular endoscopy of coronary plaquesSun, Zhonghua; Chaichana, T.; Dimpudus, F.; Adipranoto, J.; Nugroho, J. (2009)The purpose of the study is to investigate the potential diagnostic value of 3D virtual intravascular endoscopy in the visualization of coronary artery plaques in patients with suspected coronary artery disease. Ten ...