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    Class II Phosphoinositide 3-Kinases as Novel Drug Targets

    Access Status
    Fulltext not available
    Authors
    Falasca, Marco
    Hamilton, J.
    Selvadurai, M.
    Sundaram, K.
    Adamska, A.
    Thompson, P.
    Date
    2017
    Type
    Journal Article
    
    Metadata
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    Citation
    Falasca, M. and Hamilton, J. and Selvadurai, M. and Sundaram, K. and Adamska, A. and Thompson, P. 2017. Class II Phosphoinositide 3-Kinases as Novel Drug Targets. Journal of Medicinal Chemistry. 60 (1): pp. 47-65.
    Source Title
    Journal of Medicinal Chemistry
    DOI
    10.1021/acs.jmedchem.6b00963
    ISSN
    0022-2623
    School
    School of Biomedical Sciences
    URI
    http://hdl.handle.net/20.500.11937/63469
    Collection
    • Curtin Research Publications
    Abstract

    © 2016 American Chemical Society. The phosphoinositide 3-kinases (PI3Ks) are a family of lipid kinases central to regulating a wide range of important intracellular processes. Despite the vast knowledge around class I PI3Ks, the class II PI3Ks have been neglected, seemingly only due to the chronology of their discovery. Here we focus on the cellular functions of the three class II PI3K isoforms, PI3KC2α, PI3KC2β, and PI3KC2γ, in different cell systems and underline the emerging importance of these enzymes in different physiological and pathological contexts. We provide an overview on the current development of class II PI3 kinase inhibitors and outline the potential use for such inhibitors. The field is in its infancy as compared to their class I counterparts. Nevertheless, recent advances in understanding the roles of class II PI3 kinases in different pathological contexts is leading to an increased interest in the development of specific inhibitors that can provide potential novel pharmacological tools.

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