Ubiquitination and adaptive responses to BRAF inhibitors in Melanoma
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Authors
Saei, A.
Eichhorn, Pieter
Date
2018Type
Journal Article
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Saei, A. and Eichhorn, P. 2018. Ubiquitination and adaptive responses to BRAF inhibitors in Melanoma. Molecular and Cellular Oncology. 5 (5).
Source Title
Molecular and Cellular Oncology
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School
School of Pharmacy and Biomedical Sciences
Collection
Abstract
© 2018, © 2018 The Author(s). Published by Taylor & Francis. Response to targeted therapies is limited by the activation or inhibition of feedback loops. Here we report the ubiquitin specific peptidase 28/F-box WD repeat-containing protein 7 (USP28/FBW7) complex functions as a negative regulator of mitogen-activated protein kinase (MAPK) pathway by targeting v-raf murine sarcoma viral oncogene homolog B (BRAF) for degradation, a process which is lost in a large proportion of BRAF mutant melanoma patients, resulting in resistance to BRAF inhibitor therapies.
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