Show simple item record

dc.contributor.authorSaei, A.
dc.contributor.authorEichhorn, Pieter
dc.identifier.citationSaei, A. and Eichhorn, P. 2018. Ubiquitination and adaptive responses to BRAF inhibitors in Melanoma. Molecular and Cellular Oncology. 5 (5).

© 2018, © 2018 The Author(s). Published by Taylor & Francis. Response to targeted therapies is limited by the activation or inhibition of feedback loops. Here we report the ubiquitin specific peptidase 28/F-box WD repeat-containing protein 7 (USP28/FBW7) complex functions as a negative regulator of mitogen-activated protein kinase (MAPK) pathway by targeting v-raf murine sarcoma viral oncogene homolog B (BRAF) for degradation, a process which is lost in a large proportion of BRAF mutant melanoma patients, resulting in resistance to BRAF inhibitor therapies.

dc.titleUbiquitination and adaptive responses to BRAF inhibitors in Melanoma
dc.typeJournal Article
dcterms.source.titleMolecular and Cellular Oncology
curtin.departmentSchool of Pharmacy and Biomedical Sciences
curtin.accessStatusFulltext not available

Files in this item


There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record