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    Exploiting interkingdom interactions for development of small-molecule inhibitors of Candida albicans biofilm formation

    Access Status
    Open access via publisher
    Authors
    Reen, F.
    Phelan, J.
    Gallagher, L.
    Woods, D.
    Shanahan, R.
    Cano, R.
    Muimhneacháin, E.
    McGlacken, G.
    O'Gara, Fergal
    Date
    2016
    Type
    Journal Article
    
    Metadata
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    Citation
    Reen, F. and Phelan, J. and Gallagher, L. and Woods, D. and Shanahan, R. and Cano, R. and Muimhneacháin, E. et al. 2016. Exploiting interkingdom interactions for development of small-molecule inhibitors of Candida albicans biofilm formation. Antimicrobial Agents and Chemotherapy. 60 (10): pp. 5894-5905.
    Source Title
    Antimicrobial Agents and Chemotherapy
    DOI
    10.1128/AAC.00190-16
    ISSN
    0066-4804
    School
    School of Biomedical Sciences
    URI
    http://hdl.handle.net/20.500.11937/7404
    Collection
    • Curtin Research Publications
    Abstract

    © 2016, American Society for Microbiology. All Rights Reserved. A rapid decline in the development of new antimicrobial therapeutics has coincided with the emergence of new and more aggressive multidrug-resistant pathogens. Pathogens are protected from antibiotic activity by their ability to enter an aggregative biofilm state. Therefore, disrupting this process in pathogens is a key strategy for the development of next-generation antimicrobials. Here, we present a suite of compounds, based on the Pseudomonas aeruginosa 2-heptyl-4(1H)-quinolone (HHQ) core quinolone interkingdom signal structure, that exhibit noncytotoxic antibiofilm activity toward the fungal pathogen Candida albicans. In addition to providing new insights into what is a clinically important bacterium-fungus interaction, the capacity to modularize the functionality of the quinolone signals is an important advance in harnessing the therapeutic potential of signaling molecules in general. This provides a platform for the development of potent next-generation small-molecule therapeutics targeting clinically relevant fungal pathogens.

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