Show simple item record

dc.contributor.authorReen, F.
dc.contributor.authorPhelan, J.
dc.contributor.authorGallagher, L.
dc.contributor.authorWoods, D.
dc.contributor.authorShanahan, R.
dc.contributor.authorCano, R.
dc.contributor.authorMuimhneacháin, E.
dc.contributor.authorMcGlacken, G.
dc.contributor.authorO'Gara, Fergal
dc.identifier.citationReen, F. and Phelan, J. and Gallagher, L. and Woods, D. and Shanahan, R. and Cano, R. and Muimhneacháin, E. et al. 2016. Exploiting interkingdom interactions for development of small-molecule inhibitors of Candida albicans biofilm formation. Antimicrobial Agents and Chemotherapy. 60 (10): pp. 5894-5905.

© 2016, American Society for Microbiology. All Rights Reserved. A rapid decline in the development of new antimicrobial therapeutics has coincided with the emergence of new and more aggressive multidrug-resistant pathogens. Pathogens are protected from antibiotic activity by their ability to enter an aggregative biofilm state. Therefore, disrupting this process in pathogens is a key strategy for the development of next-generation antimicrobials. Here, we present a suite of compounds, based on the Pseudomonas aeruginosa 2-heptyl-4(1H)-quinolone (HHQ) core quinolone interkingdom signal structure, that exhibit noncytotoxic antibiofilm activity toward the fungal pathogen Candida albicans. In addition to providing new insights into what is a clinically important bacterium-fungus interaction, the capacity to modularize the functionality of the quinolone signals is an important advance in harnessing the therapeutic potential of signaling molecules in general. This provides a platform for the development of potent next-generation small-molecule therapeutics targeting clinically relevant fungal pathogens.

dc.publisherAmerican Society for Microbiology
dc.titleExploiting interkingdom interactions for development of small-molecule inhibitors of Candida albicans biofilm formation
dc.typeJournal Article
dcterms.source.titleAntimicrobial Agents and Chemotherapy
curtin.departmentSchool of Biomedical Sciences
curtin.accessStatusOpen access via publisher

Files in this item


There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record