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dc.contributor.authorMeylakh, N.
dc.contributor.authorMarciszewski, K.K.
dc.contributor.authorHarrington, Flavia
dc.contributor.authorMacefield, V.G.
dc.contributor.authorMacey, P.M.
dc.contributor.authorHenderson, L.A.
dc.date.accessioned2020-06-09T03:33:29Z
dc.date.available2020-06-09T03:33:29Z
dc.date.issued2018
dc.identifier.citationMeylakh, N. and Marciszewski, K.K. and Di Pietro, F. and Macefield, V.G. and Macey, P.M. and Henderson, L.A. 2018. Deep in the brain: Changes in subcortical function immediately preceding a migraine attack. Human Brain Mapping. 39 (6): pp. 2651-2663.
dc.identifier.urihttp://hdl.handle.net/20.500.11937/79560
dc.identifier.doi10.1002/hbm.24030
dc.description.abstract

© 2018 Wiley Periodicals, Inc.

The neural mechanism responsible for migraine remains unclear. While the role of an external trigger in migraine initiation remains vigorously debated, it is generally assumed that migraineurs display altered brain function between attacks. This idea stems from relatively few brain imaging studies with even fewer studies exploring changes in the 24 h period immediately prior to a migraine attack. Using functional magnetic resonance imaging, we measured infra-slow oscillatory activity, regional homogeneity, and connectivity strengths of resting activity in migraineurs directly before (n = 8), after (n = 11), and between migraine attacks (n = 26) and in healthy control subjects (n = 78). Comparisons between controls and each migraine group and between migraine groups were made for each of these measures. Directly prior to a migraine, increased infra-slow oscillatory activity occurred in brainstem and hypothalamic regions that also display altered activity during a migraine itself, that is, the spinal trigeminal nucleus, dorsal pons, and hypothalamus. Furthermore, these midbrain and hypothalamic sites displayed increased connectivity strengths and regional homogeneity directly prior to a migraine. Remarkably, these resting oscillatory and connectivity changes did not occur directly after or between migraine attacks and were significantly different to control subjects. These data provide evidence of altered brainstem and hypothalamic function in the period immediately before a migraine and raise the prospect that such changes contribute to the expression of a migraine attack.

dc.languageEnglish
dc.publisherWILEY
dc.relation.sponsoredbyhttp://purl.org/au-research/grants/nhmrc/1032072
dc.relation.sponsoredbyhttp://purl.org/au-research/grants/nhmrc/1059182
dc.subjectScience & Technology
dc.subjectLife Sciences & Biomedicine
dc.subjectNeurosciences
dc.subjectNeuroimaging
dc.subjectRadiology, Nuclear Medicine & Medical Imaging
dc.subjectNeurosciences & Neurology
dc.subjecthypothalamus
dc.subjectinfra-slow oscillations
dc.subjectperiaqueductal gray matter
dc.subjectspinal trigeminal nucleus
dc.subjectCORTICAL SPREADING DEPRESSION
dc.subjectTRIGEMINOVASCULAR SENSORY SYSTEM
dc.subjectNEUROPATHIC PAIN
dc.subjectSTEM ACTIVATION
dc.subjectDORSAL-HORN
dc.subjectSPINAL-CORD
dc.subjectIN-SITU
dc.subjectOSCILLATIONS
dc.subjectMECHANISMS
dc.subjectDISEASE
dc.titleDeep in the brain: Changes in subcortical function immediately preceding a migraine attack
dc.typeJournal Article
dcterms.source.volume39
dcterms.source.number6
dcterms.source.startPage2651
dcterms.source.endPage2663
dcterms.source.issn1065-9471
dcterms.source.titleHuman Brain Mapping
dc.date.updated2020-06-09T03:33:28Z
curtin.departmentSchool of Pharmacy and Biomedical Sciences
curtin.accessStatusFulltext not available
curtin.facultyFaculty of Health Sciences
curtin.contributor.orcidHarrington, Flavia [0000-0002-9642-0805]
curtin.contributor.researcheridHarrington, Flavia [P-5415-2018]
dcterms.source.eissn1097-0193
curtin.contributor.scopusauthoridHarrington, Flavia [6603432291]


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