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    Role of vitamin D metabolism in cutaneous tumour formation and progression

    Access Status
    Open access via publisher
    Authors
    Nemazannikova, N.
    Antonas, K.
    Dass, Crispin
    Date
    2013
    Type
    Journal Article
    
    Metadata
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    Citation
    Nemazannikova, Natalie and Antonas, Kiriakos and Dass, Crispin R. 2013. Role of vitamin D metabolism in cutaneous tumour formation and progression. Journal of Pharmacy and Pharmacology. 65 (1): pp. 2-10.
    Source Title
    Journal of Pharmacy and Pharmacology
    DOI
    10.1111/j.2042-7158.2012.01527.x
    ISSN
    0022-3573
    URI
    http://hdl.handle.net/20.500.11937/8215
    Collection
    • Curtin Research Publications
    Abstract

    Objectives:  Very limited information is available on the role of vitamin D in skin carcinogenesis. For most individuals, skin cancer can be readily managed with surgery; however, some patients may face life-threatening neoplasia. Sun exposure, specifically UV radiation, is a causative agent for development of skin cancer, though, somewhat ironically, sunlight through the production of vitamin D may have protective effect against some skin cancers. This review focuses on the development and progression of cutaneous carcinogenesis and the role of vitamin D in the prevention of the initiation and progression of lethal skin cancers.Key findings:  Vitamin D is involved in regulation of multiple signalling pathways that have implications in carcinogenesis. Skin cancer metastasis depends on the tumour microenvironment, where vitamin D metabolites play a key role in prevention of certain molecular events involved in tumour progression. The vitamin D receptor (VDR) is a well-known potent regulator of cellular growth and differentiation.Summary:  The VDR's possible involvement in cell death, tumour microenvironment and angiogenesis makes it a candidate agent for cancer regulation.

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