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dc.contributor.authorNemazannikova, N.
dc.contributor.authorAntonas, K.
dc.contributor.authorDass, Crispin
dc.identifier.citationNemazannikova, Natalie and Antonas, Kiriakos and Dass, Crispin R. 2013. Role of vitamin D metabolism in cutaneous tumour formation and progression. Journal of Pharmacy and Pharmacology. 65 (1): pp. 2-10.

Objectives:  Very limited information is available on the role of vitamin D in skin carcinogenesis. For most individuals, skin cancer can be readily managed with surgery; however, some patients may face life-threatening neoplasia. Sun exposure, specifically UV radiation, is a causative agent for development of skin cancer, though, somewhat ironically, sunlight through the production of vitamin D may have protective effect against some skin cancers. This review focuses on the development and progression of cutaneous carcinogenesis and the role of vitamin D in the prevention of the initiation and progression of lethal skin cancers.Key findings:  Vitamin D is involved in regulation of multiple signalling pathways that have implications in carcinogenesis. Skin cancer metastasis depends on the tumour microenvironment, where vitamin D metabolites play a key role in prevention of certain molecular events involved in tumour progression. The vitamin D receptor (VDR) is a well-known potent regulator of cellular growth and differentiation.Summary:  The VDR's possible involvement in cell death, tumour microenvironment and angiogenesis makes it a candidate agent for cancer regulation.

dc.publisherJohn Wiley & Sons Ltd.
dc.subjectskin cancer
dc.subjectdermal fibroblast
dc.subjectvitamin D
dc.titleRole of vitamin D metabolism in cutaneous tumour formation and progression
dc.typeJournal Article
dcterms.source.titleJournal of Pharmacy and Pharmacology
curtin.accessStatusOpen access via publisher

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