Cutting-edge biotechnological advancement in islet delivery using pancreatic and cellular approaches.
MetadataShow full item record
There are approximately 1 billion prediabetic people worldwide, and the global cost for diabetes mellitus (DM) is estimated to be $825 billion. In regard to Type 1 DM, transplanting a whole pancreas or its islets has gained the attention of researchers in the last few decades. Recent studies showed that islet transplantation (ILT) containing insulin-producing β cells is the most notable advancement cure for Type 1 DM. However, this procedure has been hindered by shortage and lack of sufficient islet donors and the need for long-term immunosuppression of any potential graft rejection. The strategy of encapsulation may avoid the rejection of stem-cell-derived allogeneic islets or xenogeneic islets. This review article describes various biotechnology features in encapsulation-of-islet-cell therapy for humans, including the use of bile acids.
Showing items related by title, author, creator and subject.
Vessel network architecture of adult human islets promotes distinct cell-cell interactions in situ and is altered after transplantationCohrs, C.; Chen, C.; Jahn, S.; Stertmann, J.; Chmelova, H.; Weitz, J.; Bähr, A.; Klymiuk, N.; Steffen, A.; Ludwig, B.; Kamvissi, V.; Wolf, E.; Bornstein, S.; Solimena, Michele; Speier, S. (2017)Copyright © 2017 Endocrine Society. Islet-cell hormone release is modulated by signals from endothelial and endocrine cells within the islet. However, models of intraislet vascularization and paracrine cell signaling are ...
Carlessi, Rodrigo; Lemos, N.; Dias, A.; Oliveira, F.; Brondani, L.; Canani, L.; Bauer, A.; Leitão, C.; Crispim, D. (2014)Islet quality loss after isolation from brain-dead donors still hinders the implementation of human islet transplantation for treatment of type 1 diabetes. In this scenario, systemic inflammation elicited by donor brain ...
Lu, Y.; Jin, X.; Chen, Younan; Li, S.; Yuan, Y.; Mai, G.; Tian, B.; Long, D.; Zhang, J.; Zeng, L.; Li, Y.; Cheng, J. (2010)Hypoxia/reoxygenation (H/R)-induced injury is the key factor associated with islet graft dysfunction. This study aims to examine the effect of mesenchymal stem cells (MSCs) on islet survival and insulin secretion under ...