Cutting-edge biotechnological advancement in islet delivery using pancreatic and cellular approaches.
dc.contributor.author | Elnashar, Magdy | |
dc.contributor.author | Vaccarezza, Mauro | |
dc.contributor.author | Al-Salami, Hani | |
dc.date.accessioned | 2021-02-17T08:20:09Z | |
dc.date.available | 2021-02-17T08:20:09Z | |
dc.date.issued | 2020 | |
dc.identifier.citation | Elnashar, M. and Vaccarezza, M. and Al-Salami, H. 2020. Cutting-edge biotechnological advancement in islet delivery using pancreatic and cellular approaches. Future Science OA. 7 (3): FSO660. | |
dc.identifier.uri | http://hdl.handle.net/20.500.11937/82630 | |
dc.identifier.doi | 10.2144/fsoa-2020-0105 | |
dc.description.abstract |
There are approximately 1 billion prediabetic people worldwide, and the global cost for diabetes mellitus (DM) is estimated to be $825 billion. In regard to Type 1 DM, transplanting a whole pancreas or its islets has gained the attention of researchers in the last few decades. Recent studies showed that islet transplantation (ILT) containing insulin-producing β cells is the most notable advancement cure for Type 1 DM. However, this procedure has been hindered by shortage and lack of sufficient islet donors and the need for long-term immunosuppression of any potential graft rejection. The strategy of encapsulation may avoid the rejection of stem-cell-derived allogeneic islets or xenogeneic islets. This review article describes various biotechnology features in encapsulation-of-islet-cell therapy for humans, including the use of bile acids. | |
dc.language | eng | |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
dc.subject | Type 1 diabetes | |
dc.subject | auto-transplantation | |
dc.subject | bile acid | |
dc.subject | diabetes treatment | |
dc.subject | encapsulation | |
dc.subject | human pancreas | |
dc.subject | pancreatic islets | |
dc.subject | stem cells | |
dc.subject | transplantation | |
dc.title | Cutting-edge biotechnological advancement in islet delivery using pancreatic and cellular approaches. | |
dc.type | Journal Article | |
dcterms.source.volume | 7 | |
dcterms.source.number | 3 | |
dcterms.source.startPage | FSO660 | |
dcterms.source.issn | 2056-5623 | |
dcterms.source.title | Future Science OA | |
dc.date.updated | 2021-02-17T08:20:09Z | |
curtin.department | Curtin Medical School | |
curtin.accessStatus | Open access | |
curtin.faculty | Centre for Aboriginal Studies | |
curtin.faculty | Faculty of Health Sciences | |
curtin.contributor.orcid | Al-Salami, Hani [0000-0003-0049-6969] | |
curtin.contributor.orcid | Elnashar, Magdy [0000-0001-9936-3271] | |
curtin.contributor.orcid | Vaccarezza, Mauro [0000-0003-3060-318X] | |
curtin.contributor.researcherid | Al-Salami, Hani [D-2509-2011] | |
dcterms.source.eissn | 2056-5623 | |
curtin.contributor.scopusauthorid | Al-Salami, Hani [24330693200] | |
curtin.contributor.scopusauthorid | Elnashar, Magdy [6507505187] | |
curtin.contributor.scopusauthorid | Vaccarezza, Mauro [6701350504] |