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    Antidiabetic effects and mechanisms of action of γ-conglutin from lupin seeds

    Access Status
    In process
    Authors
    Tapadia, M.
    Johnson, Stuart
    Utikar, Ranjeet
    Newsholme, Philip
    Carlessi, Rodrigo
    Date
    2021
    Type
    Journal Article
    
    Metadata
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    Citation
    Tapadia, M. and Johnson, S. and Utikar, R. and Newsholme, P. and Carlessi, R. 2021. Antidiabetic effects and mechanisms of action of γ-conglutin from lupin seeds. Journal of Functional Foods. 87: ARTN 104786.
    Source Title
    Journal of Functional Foods
    DOI
    10.1016/j.jff.2021.104786
    ISSN
    1756-4646
    Faculty
    Faculty of Science and Engineering
    Faculty of Science and Engineering
    Faculty of Health Sciences
    Faculty of Health Sciences
    School
    School of Molecular and Life Sciences (MLS)
    WASM: Minerals, Energy and Chemical Engineering
    Curtin Medical School
    Curtin Medical School
    URI
    http://hdl.handle.net/20.500.11937/90173
    Collection
    • Curtin Research Publications
    Abstract

    The glucose modulating properties of lupin have been attributed to its seed protein γ-conglutin. Here we explored the antidiabetic potential of γ-conglutin purified from lupin seeds in-vitro. To mimic the effects of an orally administered supplement, purified γ-conglutin was hydrolysed by gastrointestinal proteolytic enzymes and the resulting peptides evaluated for their antidiabetic effects in pancreatic β-cells and primary human skeletal muscle myotubes. γ-conglutin peptides did not promote insulin secretion in β-cells but elicited a potent insulin-mimetic action by activating insulin signalling pathways responsible for glycogen, protein synthesis, and glucose transport into myotubes. Additionally, the peptides potently suppressed the activity of DPP4 indicating their potential to increase the half-life of incretin hormones in circulation. These results substantiate the health benefits of consuming lupin seeds as part of a healthy diet and can drive the current market for lupins from primarily stockfeed, towards value-added lupin-based food products for human consumption.

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