Show simple item record

dc.contributor.authorTapadia, M.
dc.contributor.authorJohnson, Stuart
dc.contributor.authorUtikar, Ranjeet
dc.contributor.authorNewsholme, Philip
dc.contributor.authorCarlessi, Rodrigo
dc.date.accessioned2023-01-25T02:26:11Z
dc.date.available2023-01-25T02:26:11Z
dc.date.issued2021
dc.identifier.citationTapadia, M. and Johnson, S. and Utikar, R. and Newsholme, P. and Carlessi, R. 2021. Antidiabetic effects and mechanisms of action of γ-conglutin from lupin seeds. Journal of Functional Foods. 87: ARTN 104786.
dc.identifier.urihttp://hdl.handle.net/20.500.11937/90173
dc.identifier.doi10.1016/j.jff.2021.104786
dc.description.abstract

The glucose modulating properties of lupin have been attributed to its seed protein γ-conglutin. Here we explored the antidiabetic potential of γ-conglutin purified from lupin seeds in-vitro. To mimic the effects of an orally administered supplement, purified γ-conglutin was hydrolysed by gastrointestinal proteolytic enzymes and the resulting peptides evaluated for their antidiabetic effects in pancreatic β-cells and primary human skeletal muscle myotubes. γ-conglutin peptides did not promote insulin secretion in β-cells but elicited a potent insulin-mimetic action by activating insulin signalling pathways responsible for glycogen, protein synthesis, and glucose transport into myotubes. Additionally, the peptides potently suppressed the activity of DPP4 indicating their potential to increase the half-life of incretin hormones in circulation. These results substantiate the health benefits of consuming lupin seeds as part of a healthy diet and can drive the current market for lupins from primarily stockfeed, towards value-added lupin-based food products for human consumption.

dc.languageEnglish
dc.publisherELSEVIER
dc.subjectScience & Technology
dc.subjectLife Sciences & Biomedicine
dc.subjectFood Science & Technology
dc.subjectNutrition & Dietetics
dc.subjectLupin seeds
dc.subjectgamma-conglutin
dc.subjectAntidiabetic
dc.subjectInsulin mimetic
dc.subjectDPP4 inhibitor
dc.subjectGLUCAGON-LIKE PEPTIDE-1
dc.subjectWHEY-PROTEIN
dc.subjectDIPEPTIDYL PEPTIDASE-4
dc.subjectPOSTPRANDIAL GLUCOSE
dc.subjectALPHA-GLUCOSIDASE
dc.subjectFUNCTIONAL FOODS
dc.subjectLOWERING PROTEIN
dc.subjectBLOOD-GLUCOSE
dc.subjectIN-VITRO
dc.subjectINSULIN
dc.titleAntidiabetic effects and mechanisms of action of γ-conglutin from lupin seeds
dc.typeJournal Article
dcterms.source.volume87
dcterms.source.issn1756-4646
dcterms.source.titleJournal of Functional Foods
dc.date.updated2023-01-25T02:26:08Z
curtin.departmentSchool of Molecular and Life Sciences (MLS)
curtin.departmentWASM: Minerals, Energy and Chemical Engineering
curtin.departmentCurtin Medical School
curtin.departmentCurtin Medical School
curtin.accessStatusIn process
curtin.facultyFaculty of Science and Engineering
curtin.facultyFaculty of Science and Engineering
curtin.facultyFaculty of Health Sciences
curtin.facultyFaculty of Health Sciences
curtin.contributor.orcidJohnson, Stuart [0000-0001-8357-797X]
curtin.contributor.orcidNewsholme, Philip [0000-0002-0500-6984]
curtin.contributor.orcidCarlessi, Rodrigo [0000-0003-0038-7391]
curtin.contributor.researcheridJohnson, Stuart [B-5174-2012]
curtin.contributor.researcheridNewsholme, Philip [D-4939-2016]
curtin.identifier.article-numberARTN 104786
dcterms.source.eissn2214-9414
curtin.contributor.scopusauthoridUtikar, Ranjeet [6506153070]
curtin.contributor.scopusauthoridJohnson, Stuart [55466678800] [56683182000]
curtin.contributor.scopusauthoridNewsholme, Philip [55673633700] [57203030304]
curtin.contributor.scopusauthoridCarlessi, Rodrigo [14520298500]


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record