Pigment epithelium-derived factor and menopause in metastatic breast cancer
Access Status
Fulltext not available
Embargo Lift Date
2025-07-10
Authors
Brook, Naomi Louise
Date
2022Supervisor
Crispin Dass
Arunasalam Dharmarajan
Arlene Chan
Type
Thesis
Award
PhD
Metadata
Show full item recordFaculty
Health Sciences
School
School of Pharmacy
Collection
Abstract
This thesis investigated PEDF and menopause in metastatic breast cancer. Using immunohistochemistry and immunocytochemistry staining techniques, and cell-based functional assays, this thesis found that PEDF expression, anti-metastatic function and potential functional mechanisms are regulated by post-menopausal oestrogen levels in oestrogen receptor positive breast cancer and by pre-menopausal oestrogen levels in triple negative breast cancer. This thesis identifies two potential breast cancer patient populations who may derive greater clinical benefit from future therapeutic PEDF development.
Related items
Showing items related by title, author, creator and subject.
-
Si, Si; Boyle, T.; Heyworth, J.; Glass, D.; Saunders, C.; Fritschi, Lin (2015)© 2015 Springer Science+Business Media New York To investigate the association between different types of physical activity (PA) and breast cancer. A case–control study of breast cancer was conducted in Western Australia ...
-
Cordina-Duverger, E.; Menegaux, F.; Popa, A.; Rabstein, S.; Harth, V.; Pesch, B.; Brüning, T.; Fritschi, Lin; Glass, D.; Heyworth, J.; Erren, T.; Castaño-Vinyals, G.; Papantoniou, K.; Espinosa, A.; Kogevinas, M.; Grundy, A.; Spinelli, J.; Aronson, K.; Guénel, P. (2018)© 2018 Springer Science+Business Media B.V., part of Springer Nature Night shift work has been suspected to increase breast cancer risk but epidemiological studies have been inconsistent due to heterogeneous assessment ...
-
Kemp, A.; Preen, D.; Saunders, C.; Boyle, F.; Bulsara, M.; Holman, C.; Malacova, Eva; Roughead, E. (2014)Background: Australian clinical guidelines recommend endocrine therapy for all women with hormone-dependent early breast cancer. Guidelines specify tamoxifen as first-line therapy for pre-menopausal women, and tamoxifen ...