Show simple item record

dc.contributor.authorBrook, Naomi Louise
dc.contributor.supervisorCrispin Dassen_US
dc.contributor.supervisorArunasalam Dharmarajanen_US
dc.contributor.supervisorArlene Chanen_US

This thesis investigated PEDF and menopause in metastatic breast cancer. Using immunohistochemistry and immunocytochemistry staining techniques, and cell-based functional assays, this thesis found that PEDF expression, anti-metastatic function and potential functional mechanisms are regulated by post-menopausal oestrogen levels in oestrogen receptor positive breast cancer and by pre-menopausal oestrogen levels in triple negative breast cancer. This thesis identifies two potential breast cancer patient populations who may derive greater clinical benefit from future therapeutic PEDF development.

dc.publisherCurtin Universityen_US
dc.titlePigment epithelium-derived factor and menopause in metastatic breast canceren_US
curtin.departmentSchool of Pharmacyen_US
curtin.accessStatusFulltext not availableen_US
curtin.facultyHealth Sciencesen_US

Files in this item


This item appears in the following Collection(s)

Show simple item record