Show simple item record

dc.contributor.authorChaliha, Devahuti
dc.contributor.authorVaccarezza, Mauro
dc.contributor.authorCharng, Jason
dc.contributor.authorChen, Fred K
dc.contributor.authorLim, Amy
dc.contributor.authorDrummond, Peter
dc.contributor.authorTakechi, Ryusuke
dc.contributor.authorLam, Virginie
dc.contributor.authorDhaliwal, Satvinder S
dc.contributor.authorMamo, John
dc.contributor.editorYoshimoto, Takeshi
dc.date.accessioned2024-04-16T01:48:03Z
dc.date.available2024-04-16T01:48:03Z
dc.date.issued2024
dc.identifier.citationChaliha, D. and Vaccarezza, M. and Charng, J. and Chen, F.K. and Lim, A. and Drummond, P. and Takechi, R. et al. 2024. Using optical coherence tomography and optical coherence tomography angiography to delineate neurovascular homeostasis in migraine: a review. Frontiers in Neuroscience. 18: 1376282.
dc.identifier.urihttp://hdl.handle.net/20.500.11937/94861
dc.identifier.doi10.3389/fnins.2024.1376282
dc.description.abstract

Migraine is one of the world’s most debilitating disorders, and it has recently been shown that changes in the retina can be a potential biomarker for the disease. These changes can be detected by optical coherence tomography (OCT), which measures retinal thickness, and optical coherence tomography angiography (OCTA), which measures vessel density. We searched the databases Google Scholar, ProQuest, Scopus, and Web of Science for studies in English using OCT and OCTA in migraineurs, using the search terms “optical coherence tomography,” “OCT,” “optical coherence tomography angiography,” “OCTA” and “migraine.” We found 73 primary studies, 11 reviews, and 8 metaanalyses pertaining to OCT and OCTA findings in migraineurs. They showed that migraineurs had reduced retinal thickness (via OCT), retinal vessel density, and greater foveal avascular zone area (via OCTA) than controls. OCTA changes reflect a perfusion compromise occurring in migraineurs as opposed to in healthy controls. OCT and OCTA deficits were worse in migraine-with-aura and chronic migraine than in migraine-without-aura and episodic migraine. Certain areas of the eye, such as the fovea, may be more vulnerable to these perfusion changes than other parts. Direct comparison between study findings is difficult because of the heterogeneity between the studies in terms of both methodology and analysis. Moreover, as almost all case–control studies were cross-sectional, more longitudinal cohort studies are needed to determine cause and effect between migraine pathophysiology and OCT/OCTA findings. Current evidence suggests both OCT and OCTA may serve as retinal markers for migraineurs, and further research in this field will hopefully enable us to better understand the vascular changes associated with migraine, perhaps also providing a new diagnostic and therapeutic biomarker.

dc.languageEnglish
dc.publisherFrontiers Media
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectoptical coherence tomography
dc.subjectoptical coherence tomography angiography (OCTA)
dc.subjectmigraine
dc.subjectretina
dc.subjectchoroid
dc.subjectvasculature
dc.subjectvasodilation
dc.subjectvasoconstriction
dc.titleUsing optical coherence tomography and optical coherence tomography angiography to delineate neurovascular homeostasis in migraine: a review
dc.typeJournal Article
dcterms.source.volume18
dcterms.source.startPage1
dcterms.source.endPage16
dcterms.source.issn1662-453X
dcterms.source.titleFrontiers in Neuroscience
dc.date.updated2024-04-16T01:48:01Z
curtin.departmentCurtin Medical School
curtin.accessStatusOpen access
curtin.facultyFaculty of Health Sciences
curtin.contributor.orcidVaccarezza, Mauro [0000-0003-3060-318X]
curtin.identifier.article-number1376282
curtin.identifier.article-number1376282
curtin.contributor.scopusauthoridVaccarezza, Mauro [6701350504]
curtin.repositoryagreementV3


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record

http://creativecommons.org/licenses/by/4.0/
Except where otherwise noted, this item's license is described as http://creativecommons.org/licenses/by/4.0/