The spinal precerebellar nuclei: Calcium binding proteins and gene expression profile in the mouse
|dc.identifier.citation||Fu, Yuhong and Sengul, Gulgun and Paxinos, George and Watson, Charles. 2012. The spinal precerebellar nuclei: Calcium binding proteins and gene expression profile in the mouse. Neuroscience Letters. 518 (2): pp. 161-166.|
We have localized the spinocerebellar neuron groups in C57BL/6J mice by injecting the retrograde neuronal tracer Fluoro-Gold into the cerebellum and examined the distribution of SMI 32 and the calcium-binding proteins (CBPs), calbindin-D-28K (Cb), calretinin (Cr), and parvalbumin (Pv) in the spinal precerebellar nuclei. The spinal precerebellar neuron clusters identified were the dorsal nucleus, central cervical nucleus, lumbar border precerebellar nucleus, lumbar precerebellar nucleus, and sacral precerebellar nucleus. Some dispersed neurons in the deep dorsal horn and spinal laminae 6–8 also projected to the cerebellum. Cb, Cr, Pv, and SMI 32 were present in all major spinal precerebellar nuclei and Pv was the most commonly observed CBP. A number of genes expressed in hindbrain precerebellar nuclei are also expressed in spinal precerebellar groups, but there were some differences in gene expression profile between the different spinal precerebellar nuclei, pointing to functional diversity amongst them.
|dc.subject||Calcium binding proteins|
|dc.title||The spinal precerebellar nuclei: Calcium binding proteins and gene expression profile in the mouse|
NOTICE: this is the author’s version of a work that was accepted for publication in Neuroscience Letters. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Neuroscience Letters, Vol. 518 Issue 2, 19 June