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Hemodynamic Effect of Calcifed Plaque on Blood Flow in Carotid Artery Disease: A Preliminary Study

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Open access
Authors
Sun, Zhonghua
Ng, Curtise
Bibombe, P.
Chaichana, T.
Date
2009
Type
Conference Paper

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Citation
Sun, Zhonghua and Ng, Curtise and Bibombe, Patrice and Chaichana, Thanapong. 2009. Hemodynamic Effect of Calcifed Plaque on Blood Flow in Carotid Artery Disease: A Preliminary Study, in The 3rd International Conference on Bioinformatics and Biomedical Engineering (iCBBE) 2009 (ed), The 3rd International Conference on Bioinformatics and Biomedical Engineering (iCBBE) 2009, Jun 11 2009. Beijing.
Source Title
The 3rd International Conference on Bioinformatics and Biomedical Engineering (iCBBE) 2009
Source Conference
The 3rd International Conference on Bioinformatics and Biomedical Engineering (iCBBE) 2009
Faculty
School of Science and Computing
Faculty of Science and Engineering
Department of Imaging and Applied Physics
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Abstract

The purpose of the study is to investigate the hemodynamic effect of calcified carotid plaque on blood flow in patients diagnosed with carotid artery disease. Two carotid artery models were generated based on a patient data, with normal and calcified carotid artery appearances. Circular calcified carotid plaque was found at the carotid bifurcation based on 3D computed tomography images. A computational fluid dynamics was performed to analyze the changes of blood flow in different situations. Our results showed that apparent turbulence was found in the diastolic phase at the carotid bifurcation in normal carotid artery geometry. In the presence of the calcified plaque, the flow velocity was increased to some extent, indicating the effect of plaque on hemodynamic changes. Wall shear stress was noticed to be maximal at the aortic bifurcation, and this indicates the potential risk of developing stenosis at this area. Our preliminary study demonstrates fluid structure interaction between calcified plaque and artery in terms of flow changes and wall shear stress.