The Emerging Role of PEDF in Stem Cell Biology

Elahy, Mina; Baindur-Hudson, Swati; Dass, Crispin

doi:10.1155/2012/239091

190907_78265_Jnl_Biomed_Biotech3.pdf (1.063Mb)

Access Status

Open access

Authors

Elahy, Mina

Baindur-Hudson, Swati

Dass, Crispin

Date

2012

Type

Journal Article

Metadata

Show full item record

Citation

Elahy, Mina and Baindur-Hudson, Swati and Dass, Crispin R. 2012. The Emerging Role of PEDF in Stem Cell Biology. Journal of Biomedicine and Biotechnology. 2012: Article ID 239091.

Source Title

Journal of Biomedicine and Biotechnology

DOI

10.1155/2012/239091

ISSN

2314-6133

Remarks

This open access article is distributed under the Creative Commons license http://creativecommons.org/licenses/by/3.0/

URI

http://hdl.handle.net/20.500.11937/32715

Collection

Curtin Research Publications

Abstract

Encoded by a single gene, PEDF is a 50 kDa glycoprotein that is highly conserved and is widely expressed among many tissues. Most secreted PEDF deposits within the extracellular matrix, with cell-type-specific functions. While traditionally PEDF is known as a strong antiangiogenic factor, more recently, as this paper highlights, PEDF has been linked with stem cell biology, and there is now accumulating evidence demonstrating the effects of PEDF in a variety of stem cells, mainly in supporting stem cell survival and maintaining multipotency.