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dc.contributor.authorWedding, J.
dc.contributor.authorHarris, H.
dc.contributor.authorBader, C.
dc.contributor.authorPlush, S.
dc.contributor.authorMak, R.
dc.contributor.authorMassi, M.
dc.contributor.authorBrooks, D.
dc.contributor.authorLai, B.
dc.contributor.authorVogt, S.
dc.contributor.authorWerrett, M.
dc.contributor.authorSimpson, Peter
dc.contributor.authorSkelton, B.
dc.contributor.authorStagni, S.
dc.date.accessioned2017-01-30T13:33:14Z
dc.date.available2017-01-30T13:33:14Z
dc.date.created2017-01-08T19:31:01Z
dc.date.issued2016
dc.identifier.citationWedding, J. and Harris, H. and Bader, C. and Plush, S. and Mak, R. and Massi, M. and Brooks, D. et al. 2016. Intracellular distribution and stability of a luminescent rhenium(i) tricarbonyl tetrazolato complex using epifluorescence microscopy in conjunction with X-ray fluorescence imaging. Metallomics. 9 (4): pp. 382-390.
dc.identifier.urihttp://hdl.handle.net/20.500.11937/32821
dc.identifier.doi10.1039/c6mt00243a
dc.description.abstract

Optical epifluorescence microscopy was used in conjunction with X-ray fluorescence imaging to monitor the stability and intracellular distribution of the luminescent rhenium(i) complex fac-[Re(CO)3(phen)L], where phen = 1,10-phenathroline and L = 5-(4-iodophenyl)tetrazolato, in 22Rv1 cells. The rhenium complex showed no signs of ancillary ligand dissociation, a conclusion based on data obtained via X-ray fluorescence imaging aligning iodine and rhenium distributions. A diffuse reticular localisation was detected for the complex in the nuclear/perinuclear region of cells, by either optical or X-ray fluorescence imaging techniques. X-ray fluorescence also showed that the rhenium complex disrupted the homeostasis of some biologically relevant elements, such as chlorine, potassium and zinc.

dc.relation.sponsoredbyhttp://purl.org/au-research/grants/arc/FT130100033
dc.titleIntracellular distribution and stability of a luminescent rhenium(i) tricarbonyl tetrazolato complex using epifluorescence microscopy in conjunction with X-ray fluorescence imaging.
dc.typeJournal Article
dcterms.source.titleMetallomics
curtin.departmentNanochemistry Research Institute
curtin.accessStatusFulltext not available


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