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    A novel folic acid-conjugated TiO2–SiO2 photosensitizer for cancer targeting in photodynamic therapy

    226456_226456.pdf (1.723Mb)
    Access Status
    Open access
    Authors
    Feng, Xiaohui
    Zhang, S.
    Wu, H.
    Lou, Xia
    Date
    2015
    Type
    Journal Article
    
    Metadata
    Show full item record
    Citation
    Feng, X. and Zhang, S. and Wu, H. and Lou, X. 2015. A novel folic acid-conjugated TiO2–SiO2 photosensitizer for cancer targeting in photodynamic therapy. Colloids and Surfaces B: Biointerfaces. 125 (1): pp. 197-205.
    Source Title
    Colloids and Surfaces B: Biointerfaces
    DOI
    10.1016/j.colsurfb.2014.11.035
    ISSN
    0927-7765
    School
    Department of Chemical Engineering
    URI
    http://hdl.handle.net/20.500.11937/37859
    Collection
    • Curtin Research Publications
    Abstract

    In this paper, a novel folic acid-conjugated silica-coated titanium dioxide (TiO2–SiO2) photosensitizer was synthesized and characterized using various analytical instruments. The photosensitizer was further assessed with regards to its photoreactivity, cellular and hemocompatibility, cell internalization, and phototoxicity. Conjugating folic acid with TiO2–SiO2 has shown a significantly improved compatibility of the nanoparticles with the mouse fibroblast cells (L929) at 24 h. An improved compatibility with the human nasopharyngeal epidermoid cancer (KB) cells was also demonstrated, but to a slightly reduced degree. Enhanced cell internalization was well demonstrated in the TiO2–SiO2 folate nanoparticles. Upon exposure to UV light, TiO2–SiO2 folate nanoparticles maintained a high level photodynamic reactivity and yielded a 38–43% photo-killing of KB cells. The photo-killing effect increased with increasing dosage in the investigated concentration range of 50–100 μg ml−1.

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