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dc.contributor.authorFeng, Xiaohui
dc.contributor.authorZhang, S.
dc.contributor.authorWu, H.
dc.contributor.authorLou, Xia
dc.date.accessioned2017-01-30T14:09:15Z
dc.date.available2017-01-30T14:09:15Z
dc.date.created2015-05-22T08:32:17Z
dc.date.issued2015
dc.identifier.citationFeng, X. and Zhang, S. and Wu, H. and Lou, X. 2015. A novel folic acid-conjugated TiO2–SiO2 photosensitizer for cancer targeting in photodynamic therapy. Colloids and Surfaces B: Biointerfaces. 125 (1): pp. 197-205.
dc.identifier.urihttp://hdl.handle.net/20.500.11937/37859
dc.identifier.doi10.1016/j.colsurfb.2014.11.035
dc.description.abstract

In this paper, a novel folic acid-conjugated silica-coated titanium dioxide (TiO2–SiO2) photosensitizer was synthesized and characterized using various analytical instruments. The photosensitizer was further assessed with regards to its photoreactivity, cellular and hemocompatibility, cell internalization, and phototoxicity. Conjugating folic acid with TiO2–SiO2 has shown a significantly improved compatibility of the nanoparticles with the mouse fibroblast cells (L929) at 24 h. An improved compatibility with the human nasopharyngeal epidermoid cancer (KB) cells was also demonstrated, but to a slightly reduced degree. Enhanced cell internalization was well demonstrated in the TiO2–SiO2 folate nanoparticles. Upon exposure to UV light, TiO2–SiO2 folate nanoparticles maintained a high level photodynamic reactivity and yielded a 38–43% photo-killing of KB cells. The photo-killing effect increased with increasing dosage in the investigated concentration range of 50–100 μg ml−1.

dc.publisherElsevier BV
dc.subjectPhotodynamic therapy
dc.subjectPhoto-killing
dc.subjectTitanium dioxide nanoparticles
dc.subjectPhotosensitizer
dc.subjectFolic acid
dc.subjectTargeting
dc.titleA novel folic acid-conjugated TiO2–SiO2 photosensitizer for cancer targeting in photodynamic therapy
dc.typeJournal Article
dcterms.source.volume125
dcterms.source.startPage197
dcterms.source.endPage205
dcterms.source.issn0927-7765
dcterms.source.titleColloids and Surfaces B: Biointerfaces
curtin.departmentDepartment of Chemical Engineering
curtin.accessStatusOpen access


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