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dc.contributor.authorFernandez, S.
dc.contributor.authorFrench, M.
dc.contributor.authorPrice, Patricia
dc.identifier.citationFernandez, S. and French, M. and Price, P. 2011. Immunosenescent CD57 +CD4+ T-cells accumulate and contribute to interferon-γ responses in HIV patients responding stably to ART. Disease Markers. 31 (6): pp. 337-342.

HIV-infected individuals responding to antiretroviral therapy (ART) after severe CD4+ T-cell depletion may retain low responses to recall antigens [eg: cytomegalovirus (CMV)] and altered expression of T-cell co-stimulatory molecules consistent with immunosenescence. We investigated the capacity of phenotypically senescent cells to generate cytokines in HIV patients receiving long-term ART (n = 18) and in healthy controls (n = 10). Memory T-cells were assessed by interferon (IFN)-γ ELISpot assay and flow cytometrically via IFN-γ or IL-2. Proportions of CD57brightCD28null CD4+ T-cells correlated with IFN-γ responses to CMV (p = 0.009) and anti-CD3 (p = 0.002) in HIV patients only. Proportions of CD57brightCD28null CD8+ T-cells and CD8+ T-cell IFN-γ responses to CMV peptides correlated in controls but not HIV patients. IL-2 was predominantly produced by CD28+T-cells from all donors, whereas IFN-γ was mostly produced by CD57+ T-cells. The findings provide evidence of an accumulation of immunosenescent T-cells able to make IFN-γ. This may influence the pathogenesis of secondary viral infections in HIV patients receiving ART.

dc.titleImmunosenescent CD57 +CD4+ T-cells accumulate and contribute to interferon-γ responses in HIV patients responding stably to ART
dc.typeJournal Article
dcterms.source.titleDisease Markers

This open access article is distributed under the Creative Commons license

curtin.departmentSchool of Biomedical Sciences
curtin.accessStatusOpen access

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