Akt/protein kinase B in skeletal muscle physiology and pathology
MetadataShow full item record
The Akt/protein kinase B is critical regulator of cellular homeostasis with diminished Akt activity being associated with dysregulation of cellular metabolism and cell death while the regulation of Akt function has been well characterized in vitro, much less is known regarding the function of Akt in vivo. Here we examine how skeletal muscle Akt expression and enzymatic activity are controlled, the role of Akt in the regulation of skeletal muscle contraction, stress response glucose utilization, and protein metabolism, and the potential participation of this important molecule in skeletal muscle atrophy, aging, and cancer.
Showing items related by title, author, creator and subject.
Panizzolo, F.; Maiorana, Andrew; Naylor, L.; Dembo, L.; Lloyd, D.; Green, D.; Rubenson, J. (2016)© 2016 Panizzolo et al. Background. Alterations in skeletal muscle function and architecture have been linked to the compromised exercise capacity characterizing chronic heart failure (CHF). However, how passive skeletal ...
Lifelong exercise and locally produced insulin-like growth factor-1 (IGF-1) have a modest influence on reducing age-related muscle wasting in miceMcMahon, C.; Chai, R.; Crabb, Hannah; Watson, T.; Matthews, K.; Sheard, P.; Soffe, Z.; Grounds, M.; Shavlakadze, T. (2014)The age-related loss of skeletal muscle mass and function is termed sarcopenia and has been attributed to a decline in concentrations of insulin-like growth factor-1 (IGF-1). We hypothesized that constitutively expressed ...
Differential nitric oxide levels in the blood and skeletal muscle of Type 2 diabetic subjects may be consequence of adiposity: a preliminary study.Krause, M.; Rodrigues-Krause, J.; O'Hagan, C.; De Vito, G.; Boreham, C.; Susta, D.; Newsholme, Philip; Murphy, C. (2012)Background and Aims: Nitric oxide (NO) exerts key regulatory functions including vasodilation and glucose uptake. Thus reduced NO levels are associated with insulin resistance and hypertension. In this preliminary work ...