Show simple item record

dc.contributor.authorLiu, Chongyang
dc.contributor.authorGong, Zhaohua
dc.contributor.authorTeo, Kok Lay
dc.contributor.authorFeng, E.
dc.identifier.citationLiu, C. and Gong, Z. and Teo, K.L. and Feng, E. 2016. Multi-objective optimization of nonlinear switched time-delay systems in fed-batch process. Applied Mathematical Modelling. 40 (23-24): pp. 1339-1351.

© 2016 Elsevier Inc.Maximization of productivity and minimization of consumption are two top priorities for biotechnological industry. In this paper, we model a fed-batch process as a nonlinear switched time-delay system. Taking the productivity of target product and the consumption rate of substrate as the objective functions, we present a multi-objective optimization problem involving the nonlinear switched time-delay system and subject to continuous state inequality constraints. To solve the multi-objective optimization problem, we first convert the problem into a sequence of single-objective optimization problems by using convex weighted sum and normal boundary intersection methods. A gradient-based single-objective solver incorporating constraint transcription technique is then developed to solve these single-objective optimization problems. Finally, a numerical example is provided to verify the effectiveness of the numerical solution approach. Numerical results show that the normal boundary intersection method in conjunction with the developed single-objective solver is more favourable than the convex weighted sum method.

dc.titleMulti-objective optimization of nonlinear switched time-delay systems in fed-batch process
dc.typeJournal Article
dcterms.source.titleApplied Mathematical Modelling
curtin.departmentDepartment of Mathematics and Statistics
curtin.accessStatusOpen access

Files in this item


This item appears in the following Collection(s)

Show simple item record