Curtin University Homepage
  • Library
  • Help
    • Admin

    espace - Curtin’s institutional repository

    JavaScript is disabled for your browser. Some features of this site may not work without it.
    View Item 
    • espace Home
    • espace
    • Curtin Research Publications
    • View Item
    • espace Home
    • espace
    • Curtin Research Publications
    • View Item

    Characterisation of a G9P[8] rotavirus strain identified during a gastroenteritis outbreak in Alice Springs, Australia post Rotarix™ vaccine introduction

    Access Status
    Fulltext not available
    Authors
    Donato, C.
    Cannan, D.
    Bogdanovic-Sakran, N.
    Snelling, Thomas
    Kirkwood, C.
    Date
    2012
    Type
    Journal Article
    
    Metadata
    Show full item record
    Citation
    Donato, C. and Cannan, D. and Bogdanovic-Sakran, N. and Snelling, T. and Kirkwood, C. 2012. Characterisation of a G9P[8] rotavirus strain identified during a gastroenteritis outbreak in Alice Springs, Australia post Rotarix™ vaccine introduction. Vaccine. 30 (SUPPL. 1).
    Source Title
    Vaccine
    DOI
    10.1016/j.vaccine.2011.07.119
    ISSN
    0264-410X
    School
    School of Public Health
    URI
    http://hdl.handle.net/20.500.11937/55296
    Collection
    • Curtin Research Publications
    Abstract

    A large rotavirus gastroenteritis outbreak occurred in the Alice Springs region of the Northern Territory, Australia from the 12th of March until the 11th of July 2007. The outbreak occurred five months after the introduction of the Rotarix™ vaccine. Electropherotype and sequence analysis demonstrated that a single G9P[8] strain was responsible for the outbreak and that the strain remained highly conserved during the outbreak period. The outbreak strain contained amino acid changes in regions of the VP7 and NSP4 genes, with known biological function, when compared to previously characterised G9P[8] strains from Australia and other international locations. The recent vaccine introduction was unlikely to have influenced genotype selection in this setting. Importantly, Rotarix™ vaccine was highly effective against the G9P[8] outbreak strain. © 2011 Elsevier Ltd.

    Related items

    Showing items related by title, author, creator and subject.

    • Characterization of G2P[4] rotavirus strains causing outbreaks of gastroenteritis in the Northern Territory, Australia, in 1999, 2004 and 2009
      Donato, C.; Cowley, D.; Donker, N.; Bogdanovic-Sakran, N.; Snelling, Thomas; Kirkwood, C. (2014)
      © 2014 Elsevier B.V. Outbreaks of rotavirus diarrhea cause a large disease burden in the Alice Springs region of the Northern Territory, Australia. The introduction of the rotavirus vaccine Rotarix® has been associated ...
    • Characterization of a G1P[8] rotavirus causing an outbreak of gastroenteritis in the Northern Territory, Australia, in the vaccine era
      Donato, C.; Cowley, D.; Snelling, Thomas; Akopov, A.; Kirkness, E.; Kirkwood, C. (2014)
      In 2010, a large outbreak of rotavirus gastroenteritis occurred in the Alice Springs region of the Northern Territory, Australia. The outbreak occurred 43 months after the introduction of the G1P[8] rotavirus vaccine ...
    • Case-control evaluation of the effectiveness of the G1P[8] human rotavirus vaccine during an outbreak of rotavirus G2P[4] infection in central Australia
      Snelling, Thomas; Andrews, R.; Kirkwood, C.; Culvenor, S.; Carapetis, J. (2011)
      Summary: The human rotavirus vaccine was evaluated during an outbreak of rotavirus G2P[4] infection in central Australia. No overall protective effect against hospitalization was demonstrated, raising concerns over the ...
    Advanced search

    Browse

    Communities & CollectionsIssue DateAuthorTitleSubjectDocument TypeThis CollectionIssue DateAuthorTitleSubjectDocument Type

    My Account

    Admin

    Statistics

    Most Popular ItemsStatistics by CountryMost Popular Authors

    Follow Curtin

    • 
    • 
    • 
    • 
    • 

    CRICOS Provider Code: 00301JABN: 99 143 842 569TEQSA: PRV12158

    Copyright | Disclaimer | Privacy statement | Accessibility

    Curtin would like to pay respect to the Aboriginal and Torres Strait Islander members of our community by acknowledging the traditional owners of the land on which the Perth campus is located, the Whadjuk people of the Nyungar Nation; and on our Kalgoorlie campus, the Wongutha people of the North-Eastern Goldfields.