Characterization of a G1P rotavirus causing an outbreak of gastroenteritis in the Northern Territory, Australia, in the vaccine era
|dc.identifier.citation||Donato, C. and Cowley, D. and Snelling, T. and Akopov, A. and Kirkness, E. and Kirkwood, C. 2014. Characterization of a G1P rotavirus causing an outbreak of gastroenteritis in the Northern Territory, Australia, in the vaccine era. Emerging Microbes and Infections. 3.|
In 2010, a large outbreak of rotavirus gastroenteritis occurred in the Alice Springs region of the Northern Territory, Australia. The outbreak occurred 43 months after the introduction of the G1P rotavirus vaccine Rotarix®. Forty-three infants were hospitalized during the outbreak and analysis of fecal samples from each infant revealed a G1P rotavirus strain. The outbreak strain was adapted to cell culture and neutralization assays were performed using VP7 and VP4 neutralizing monoclonal antibodies. The outbreak strain exhibited a distinct neutralization resistance pattern compared to the Rotarix® vaccine strain. Whole genome sequencing of the 2010 outbreak virus strain demonstrated numerous amino acid differences compared to the Rotarix® vaccine strain in the characterized neutralization epitopes of the VP7 and VP4 proteins. Phylogenetic analysis of the outbreak strain revealed a close genetic relationship to global strains, in particular RVA/Human-wt/BEL/BE0098/2009/ G1P and RVA/Human-wt/BEL/BE00038/2008/G1P for numerous genes. The 2010 outbreak strain was likely introduced from a globally circulating population of strains rather than evolving from an endemic Australian strain. The outbreak strain possessed antigenic differences in the VP7 and VP4 proteins compared to the Rotarix® vaccine strain. The outbreak was associated with moderate vaccine coverage and possibly low vaccine take in the population. © 2014 SSCC. All rights reserved.
|dc.publisher||Nature Publishing Group|
|dc.title||Characterization of a G1P rotavirus causing an outbreak of gastroenteritis in the Northern Territory, Australia, in the vaccine era|
|dcterms.source.title||Emerging Microbes and Infections|
|curtin.department||School of Public Health|
|curtin.accessStatus||Open access via publisher|
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