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dc.contributor.authorHartnell, David
dc.contributor.authorSchwehr, Bradley J
dc.contributor.authorGillespie-Jones, Kate
dc.contributor.authorAlwis, Dasuni
dc.contributor.authorRajan, Ramesh
dc.contributor.authorHou, Huishu
dc.contributor.authorSylvain, Nicole J
dc.contributor.authorPushie, Michael J
dc.contributor.authorKelly, Michael E
dc.contributor.authorMassi, Max
dc.contributor.authorHackett, Mark
dc.identifier.citationHartnell, D. and Schwehr, B.J. and Gillespie-Jones, K. and Alwis, D. and Rajan, R. and Hou, H. and Sylvain, N.J. et al. 2020. Imaging lipophilic regions in rodent brain tissue with halogenated BODIPY probes. Analyst. 145: pp. 3809-3813.

The effect of halogen substitution in fluorescent BODIPY species was evaluated in the context of staining lipids in situ within brain tissue sections. Herein we demonstrate that the halogenated species maintain their known in vitro affinity when applied to detect lipids in situ in brain tissue sections. Interestingly, the chlorine substituted compound revealed the highest specificify for white matter lipids. Furthermore, the halogen substituted compounds rapidly detected lipid enriched cells, in situ, associated with a case of brain pathology and neuroinflammation.

dc.titleImaging lipophilic regions in rodent brain tissue with halogenated BODIPY probes
dc.typeJournal Article
curtin.departmentSchool of Molecular and Life Sciences (MLS)
curtin.accessStatusFulltext not available
curtin.facultyFaculty of Science and Engineering
curtin.contributor.orcidHackett, Mark [0000-0002-3296-7270]
curtin.contributor.orcidMassi, Max [0000-0001-6949-4019]
curtin.contributor.scopusauthoridHackett, Mark [35240056500]
curtin.contributor.scopusauthoridMassi, Max [7102368846]

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